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Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.
Ryan, M Dominic; Parkes, Alastair L; Corbett, David; Dickie, Anthony P; Southey, Michelle; Andersen, Ole A; Stein, Daniel B; Barbeau, Olivier R; Sanzone, Angelo; Thommes, Pia; Barker, John; Cain, Ricky; Compper, Christel; Dejob, Magali; Dorali, Alain; Etheridge, Donnya; Evans, Sian; Faulkner, Adele; Gadouleau, Elise; Gorman, Timothy; Haase, Denes; Holbrow-Wilshaw, Maisie; Krulle, Thomas; Li, Xianfu; Lumley, Christopher; Mertins, Barbara; Napier, Spencer; Odedra, Rajesh; Papadopoulos, Kostas; Roumpelakis, Vasileios; Spear, Kate; Trimby, Emily; Williams, Jennifer; Zahn, Michael; Keefe, Anthony D; Zhang, Ying; Soutter, Holly T; Centrella, Paolo A; Clark, Matthew A; Cuozzo, John W; Dumelin, Christoph E; Deng, Boer; Hunt, Avery; Sigel, Eric A; Troast, Dawn M; DeJonge, Boudewijn L M.
Afiliación
  • Ryan MD; X-Biotix Therapeutics, 465 Waverly Oaks Road, Waltham, Massachusetts 02452, United States.
  • Parkes AL; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Corbett D; Evotec UK, Anti-infectives, Block 23F, Alderley Park, Cheshire SK10 4TG, U.K.
  • Dickie AP; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Southey M; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Andersen OA; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Stein DB; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany.
  • Barbeau OR; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Sanzone A; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Thommes P; Evotec UK, Anti-infectives, Block 23F, Alderley Park, Cheshire SK10 4TG, U.K.
  • Barker J; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Cain R; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Compper C; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Dejob M; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Dorali A; Evotec UK, Anti-infectives, Block 23F, Alderley Park, Cheshire SK10 4TG, U.K.
  • Etheridge D; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Evans S; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Faulkner A; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Gadouleau E; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Gorman T; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Haase D; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany.
  • Holbrow-Wilshaw M; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Krulle T; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Li X; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Lumley C; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Mertins B; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Napier S; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Odedra R; Evotec UK, Anti-infectives, Block 23F, Alderley Park, Cheshire SK10 4TG, U.K.
  • Papadopoulos K; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Roumpelakis V; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Spear K; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Trimby E; Evotec UK, Anti-infectives, Block 23F, Alderley Park, Cheshire SK10 4TG, U.K.
  • Williams J; Evotec UK, Anti-infectives, Block 23F, Alderley Park, Cheshire SK10 4TG, U.K.
  • Zahn M; Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.
  • Keefe AD; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Zhang Y; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Soutter HT; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Centrella PA; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Clark MA; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Cuozzo JW; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Dumelin CE; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Deng B; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Hunt A; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Sigel EA; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • Troast DM; X-Chem, 100 Beaver Street, Waltham, Massachusetts 02453, United States.
  • DeJonge BLM; X-Biotix Therapeutics, 465 Waverly Oaks Road, Waltham, Massachusetts 02452, United States.
J Med Chem ; 64(19): 14377-14425, 2021 10 14.
Article en En | MEDLINE | ID: mdl-34569791
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Aciltransferasas / Inhibidores Enzimáticos / Descubrimiento de Drogas / Antibacterianos Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Aciltransferasas / Inhibidores Enzimáticos / Descubrimiento de Drogas / Antibacterianos Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos