Ciprofloxacin accelerates aortic enlargement and promotes dissection and rupture in Marfan mice.

LeMaire, Scott A; Zhang, Lin; Zhang, Nicholas S; Luo, Wei; Barrish, James P; Zhang, Qianzi; Coselli, Joseph S; Shen, Ying H

LeMaire, Scott A; Zhang, Lin; Zhang, Nicholas S; Luo, Wei; Barrish, James P; Zhang, Qianzi; Coselli, Joseph S; Shen, Ying H.

Afiliación

LeMaire SA; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Tex; Cardiovascular Research Institute, Baylor College of Medicine, Houston, Tex. Electronic address: slemaire
Zhang L; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Tex.
Zhang NS; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
Luo W; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Tex.
Barrish JP; Department of Pathology, Texas Children's Hospital, Houston, Tex.
Zhang Q; Surgical Research Core, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
Coselli JS; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Tex; Cardiovascular Research Institute, Baylor College of Medicine, Houston, Tex.
Shen YH; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Tex; Cardiovascular Research Institute, Baylor College of Medicine, Houston, Tex.

J Thorac Cardiovasc Surg ; 163(3): e215-e226, 2022 03.

Article en En | MEDLINE | ID: mdl-34586071

Asunto(s)

Antibacterianos/toxicidad; Aorta/efectos de los fármacos; Aneurisma de la Aorta/inducido químicamente; Disección Aórtica/inducido químicamente; Rotura de la Aorta/inducido químicamente; Ciprofloxacina/toxicidad; Fibrilina-1/genética; Remodelación Vascular/efectos de los fármacos; Disección Aórtica/genética; Disección Aórtica/metabolismo; Disección Aórtica/patología; Animales; Aorta/metabolismo; Aorta/ultraestructura; Aneurisma de la Aorta/genética; Aneurisma de la Aorta/metabolismo; Aneurisma de la Aorta/patología; Rotura de la Aorta/genética; Rotura de la Aorta/metabolismo; Rotura de la Aorta/patología; Apoptosis/efectos de los fármacos; Dilatación Patológica; Progresión de la Enfermedad; Tejido Elástico/efectos de los fármacos; Tejido Elástico/metabolismo; Tejido Elástico/ultraestructura; Proteínas de la Matriz Extracelular/metabolismo; Femenino; Predisposición Genética a la Enfermedad; Masculino; Metaloproteinasas de la Matriz/metabolismo; Ratones Noqueados; Fenotipo; Proteína-Lisina 6-Oxidasa/metabolismo

Palabras clave

Marfan syndrome; aortic disease; ciprofloxacin

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Aorta / Aneurisma de la Aorta / Rotura de la Aorta / Ciprofloxacina / Remodelación Vascular / Fibrilina-1 / Disección Aórtica / Antibacterianos Límite: Animals Idioma: En Revista: J Thorac Cardiovasc Surg Año: 2022 Tipo del documento: Article

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