Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes.

Uehara, Shotaro; Yoneda, Nao; Higuchi, Yuichiro; Yamazaki, Hiroshi; Suemizu, Hiroshi

Uehara, Shotaro; Yoneda, Nao; Higuchi, Yuichiro; Yamazaki, Hiroshi; Suemizu, Hiroshi.

Afiliación

Uehara S; Central Institute for Experimental Animals, Kawasaki, Japan. Electronic address: s-uehara@ciea.or.jp.
Yoneda N; Central Institute for Experimental Animals, Kawasaki, Japan.
Higuchi Y; Central Institute for Experimental Animals, Kawasaki, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Suemizu H; Central Institute for Experimental Animals, Kawasaki, Japan.

Drug Metab Pharmacokinet ; 41: 100419, 2021 Dec.

Article en En | MEDLINE | ID: mdl-34624627

Asunto(s)

Aldehído Oxidasa; Hepatocitos; Aldehído Oxidasa/genética; Aldehído Oxidasa/metabolismo; Animales; Perros; Receptores ErbB/metabolismo; Cobayas; Hepatocitos/metabolismo; Humanos; Hígado/metabolismo; Ratones; Estrés Oxidativo; Conejos; Ratas; Porcinos; Porcinos Enanos/metabolismo

Palabras clave

Aldehyde oxidase; BIBX1382; Drug metabolism; Hu-liver cell; Humanized liver mouse

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hepatocitos / Aldehído Oxidasa Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2021 Tipo del documento: Article

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