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Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease.
Rimal, Suman; Li, Yu; Vartak, Rasika; Geng, Ji; Tantray, Ishaq; Li, Shuangxi; Huh, Sungun; Vogel, Hannes; Glabe, Charles; Grinberg, Lea T; Spina, Salvatore; Seeley, William W; Guo, Su; Lu, Bingwei.
Afiliación
  • Rimal S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Li Y; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Vartak R; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Geng J; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Tantray I; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Li S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Huh S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Vogel H; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Glabe C; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA.
  • Grinberg LT; Memory and Aging Center, Department of Neurology and Department of Pathology, University of California, San Francisco, CA, 94158, USA.
  • Spina S; Memory and Aging Center, Department of Neurology and Department of Pathology, University of California, San Francisco, CA, 94158, USA.
  • Seeley WW; Memory and Aging Center, Department of Neurology and Department of Pathology, University of California, San Francisco, CA, 94158, USA.
  • Guo S; Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
  • Lu B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA. bingwei@stanford.edu.
Acta Neuropathol Commun ; 9(1): 169, 2021 10 18.
Article en En | MEDLINE | ID: mdl-34663454
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ribosomas / Biosíntesis de Proteínas / Precursor de Proteína beta-Amiloide / Placa Amiloide / Enfermedad de Alzheimer / Proteostasis Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Acta Neuropathol Commun Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ribosomas / Biosíntesis de Proteínas / Precursor de Proteína beta-Amiloide / Placa Amiloide / Enfermedad de Alzheimer / Proteostasis Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Acta Neuropathol Commun Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos