Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd2+ Ions: A Complete Photophysical Analysis and Bio-Imaging Study.
ACS Omega
; 6(42): 27936-27945, 2021 Oct 26.
Article
en En
| MEDLINE
| ID: mdl-34722993
ABSTRACT
A novel triazole-bridged coumarin-benzimidazole-conjugated fluorescence sensor (4) has been developed for selective detection of Cd2+ over other competitive metal ions. The sensor exhibited quick "turn-on" responses upon interaction with a very low level of Cd2+ (14 nM). The photophysical changes in the complexation of Cd2+ with sensor 4 have been explained through the excited-state intramolecular proton transfer mechanism. The involvement of benzimidazole and triazole moieties in Cd2+ binding was confirmed by different spectroscopic techniques such as UV-vis, Fourier transform infrared, nuclear magnetic resonance, and ESI mass. The diameter of the circular shape of the sensor decreased upon complexation with Cd2+, which was confirmed by field-emission scanning electron microscopy. Furthermore, the quantum chemical (density functional theory) calculation supported the mechanism of interactions and the mode of binding of 4 toward Cd2+. The sensor was more effective for finding Cd2+ in two living cells, C6 (rat glial cell) and Hep G2 (human liver cell).
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MEDLINE
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En
Revista:
ACS Omega
Año:
2021
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Article
País de afiliación:
India