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Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling.
van Vliet, Nicolien A; Bos, Maxime M; Thesing, Carisha S; Chaker, Layal; Pietzner, Maik; Houtman, Evelyn; Neville, Matt J; Li-Gao, Ruifang; Trompet, Stella; Mustafa, Rima; Ahmadizar, Fariba; Beekman, Marian; Bot, Mariska; Budde, Kathrin; Christodoulides, Constantinos; Dehghan, Abbas; Delles, Christian; Elliott, Paul; Evangelou, Marina; Gao, He; Ghanbari, Mohsen; van Herwaarden, Antonius E; Ikram, M Arfan; Jaeger, Martin; Jukema, J Wouter; Karaman, Ibrahim; Karpe, Fredrik; Kloppenburg, Margreet; Meessen, Jennifer M T A; Meulenbelt, Ingrid; Milaneschi, Yuri; Mooijaart, Simon P; Mook-Kanamori, Dennis O; Netea, Mihai G; Netea-Maier, Romana T; Peeters, Robin P; Penninx, Brenda W J H; Sattar, Naveed; Slagboom, P Eline; Suchiman, H Eka D; Völzke, Henry; Willems van Dijk, Ko; Noordam, Raymond; van Heemst, Diana.
Afiliación
  • van Vliet NA; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
  • Bos MM; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
  • Thesing CS; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Chaker L; Amsterdam UMC, Vrije Universiteit, Department of Psychiatry, Amsterdam Public Health research institute, Amsterdam, The Netherlands.
  • Pietzner M; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Houtman E; Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands.
  • Neville MJ; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • Li-Gao R; Computational Medicine, Berlin Institute of Health (BIH), Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Trompet S; Department of Biomedical Data Sciences, section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Mustafa R; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals Foundation Trust, Oxford, UK.
  • Ahmadizar F; Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK.
  • Beekman M; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Bot M; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
  • Budde K; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Christodoulides C; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Dehghan A; Department of Biomedical Data Sciences, section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Delles C; Amsterdam UMC, Vrije Universiteit, Department of Psychiatry, Amsterdam Public Health research institute, Amsterdam, The Netherlands.
  • Elliott P; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Evangelou M; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals Foundation Trust, Oxford, UK.
  • Gao H; Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK.
  • Ghanbari M; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • van Herwaarden AE; Dementia Research Institute at Imperial College London, London, UK.
  • Ikram MA; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Jaeger M; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Jukema JW; Dementia Research Institute at Imperial College London, London, UK.
  • Karaman I; NIHR Biomedical Research Centre, Imperial College London, London, UK.
  • Karpe F; BHF Imperial College Centre for Research Excellence, Imperial College London, London, UK.
  • Kloppenburg M; Department of Mathematics, Faculty of Natural Sciences, Imperial College London, London, UK.
  • Meessen JMTA; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Meulenbelt I; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Milaneschi Y; Department of Laboratory Medicine, Radboud Laboratory for Diagnostics (RLD), Radboud University Medical Center, Nijmegen, The Netherlands.
  • Mooijaart SP; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Mook-Kanamori DO; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Netea-Maier RT; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Peeters RP; Netherlands Heart Institute, Utrecht, The Netherlands.
  • Penninx BWJH; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Sattar N; Dementia Research Institute at Imperial College London, London, UK.
  • Slagboom PE; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals Foundation Trust, Oxford, UK.
  • Suchiman HED; Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK.
  • Völzke H; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Willems van Dijk K; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
  • Noordam R; Department of Biomedical Data Sciences, section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • van Heemst D; Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands.
BMC Med ; 19(1): 266, 2021 11 03.
Article en En | MEDLINE | ID: mdl-34727949
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tirotropina / Enfermedades Cardiovasculares Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Med Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tirotropina / Enfermedades Cardiovasculares Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Med Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos