Chemoinformatics View on Bitter Taste Receptor Agonists in Food.
J Agric Food Chem
; 69(46): 13916-13924, 2021 Nov 24.
Article
en En
| MEDLINE
| ID: mdl-34762411
ABSTRACT
Food compounds with a bitter taste have a role in human health, both for their capability to influence food choice and preferences and for their possible systemic effect due to the modulation of extra-oral bitter taste receptors (TAS2Rs). Investigating the interaction of bitter food compounds with TAS2Rs is a key step to unravel their complex effects on health and to pave the way to rationally design new additives for food formulation or drugs. Here, we propose a collection of food bitter compounds, for which in vitro activity data against TAS2Rs are available. The patterns of TAS2R subtype-specific agonists were analyzed using scaffold decomposition and chemical space analysis, providing a detailed characterization of the associations between food bitter tastants and TAS2Rs.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Papilas Gustativas
/
Preparaciones Farmacéuticas
Límite:
Humans
Idioma:
En
Revista:
J Agric Food Chem
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania