Rho GTPases in Skeletal Muscle Development and Homeostasis.
Cells
; 10(11)2021 11 02.
Article
en En
| MEDLINE
| ID: mdl-34831205
ABSTRACT
Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Músculo Esquelético
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Proteínas de Unión al GTP rho
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Desarrollo de Músculos
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Homeostasis
Límite:
Animals
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Humans
Idioma:
En
Revista:
Cells
Año:
2021
Tipo del documento:
Article
País de afiliación:
España