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A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy.
Casellas, Nicolás M; Dai, Gaole; Xue, Evelyn Y; Fonseca, Alba; Ng, Dennis K P; García-Iglesias, Miguel; Torres, Tomás.
Afiliación
  • Casellas NM; Department of Organic Chemistry and Institute for Advanced Research in Chemical Sciences (IadChem), Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente, 7, Madrid 28049, Spain. tomas.torres@uam.es.
  • Dai G; IMDEA Nanociencia, c/Faraday 9, Cantoblanco, Madrid 28049, Spain.
  • Xue EY; Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China. dkpn@cuhk.edu.hk.
  • Fonseca A; Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China. dkpn@cuhk.edu.hk.
  • Ng DKP; Department of Organic Chemistry and Institute for Advanced Research in Chemical Sciences (IadChem), Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente, 7, Madrid 28049, Spain. tomas.torres@uam.es.
  • García-Iglesias M; Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China. dkpn@cuhk.edu.hk.
  • Torres T; Department of Organic Chemistry and Institute for Advanced Research in Chemical Sciences (IadChem), Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente, 7, Madrid 28049, Spain. tomas.torres@uam.es.
Chem Commun (Camb) ; 58(5): 669-672, 2022 Jan 13.
Article en En | MEDLINE | ID: mdl-34919102
ABSTRACT
A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC50 values of as low as 1.2 µM.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fotoquimioterapia Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: España
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fotoquimioterapia Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: España