Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads.
Phytochemistry
; 196: 113072, 2022 Apr.
Article
en En
| MEDLINE
| ID: mdl-34973506
ABSTRACT
Eremophila (Scrophulariaceae) is a genus of Australian desert plants, which have been used by Australian Aboriginal people for various medicinal purposes. Crude extracts of the leaf resin of Eremophila glabra (R.Br.) Ostenf. showed α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values of 19.3 ± 1.2 µg/mL and 11.8 ± 2.1 µg/mL, respectively. Dual α-glucosidase/PTP1B high-resolution inhibition profiling combined with HPLC-PDA-HRMS and NMR were used to isolate and identify the compounds providing these activities. This resulted in isolation of seven undescribed serrulatane diterpenoids, eremoglabrane A-G, together with nine previously identified serrulatane diterpenoids and flavonoids. Three of the serrulatane diterpenoids showed PTP1B inhibitory activities with IC50 values from 63.8 ± 5.8 µM to 104.5 ± 25.9 µM.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Scrophulariaceae
/
Diterpenos
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Phytochemistry
Año:
2022
Tipo del documento:
Article
País de afiliación:
Dinamarca