Adenylate kinase 1 overexpression increases locomotor activity in medaka fish.
PLoS One
; 17(1): e0257967, 2022.
Article
en En
| MEDLINE
| ID: mdl-34982774
ABSTRACT
Maintenance of the energy balance is indispensable for cell survival and function. Adenylate kinase (Ak) is a ubiquitous enzyme highly conserved among many organisms. Ak plays an essential role in energy regulation by maintaining adenine nucleotide homeostasis in cells. However, its role at the whole organism level, especially in animal behavior, remains unclear. Here, we established a model using medaka fish (Oryzias latipes) to examine the function of Ak in environmental adaptation. Medaka overexpressing the major Ak isoform Ak1 exhibited increased locomotor activity compared to that of the wild type. Interestingly, this increase was temperature dependent. Our findings suggest that cellular energy balance can modulate locomotor activity.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Oryzias
/
Adenilato Quinasa
/
Proteínas de Peces
/
Locomoción
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón