Photosynthetic microorganisms and their bioactive molecules as new product to healing wounds.
Appl Microbiol Biotechnol
; 106(2): 497-504, 2022 Jan.
Article
en En
| MEDLINE
| ID: mdl-34985569
ABSTRACT
Wounds are a public health problem due to long periods required to repair damaged skin, risk of infection, and amputations. Thus, there is a need to obtain new therapeutic agents with less side effects, more effective oxygen delivery, and increased epithelial cell migration. Photosynthetic microorganisms, such as microalgae and cyanobacteria, may be used as a source of biomolecules for the treatment of different injuries. The aim of this review article focuses on healing potential using phytoconstituents from photosynthetic microorganisms. Cyanophyte Spirulina and Chlorophyte Chlorella are more promising due to steroids, triterpenes, carbohydrates, phenols, and proteins such as lectins and phycocyanin. However, there are few reports about identification and specific function of these molecules on the skin. In other microalgae and cyanobacteria genus, high contents of pigments such as ß-carotene, chlorophyll a, allophycocyanin, and hydroxypheophytin were detected, but their effects on phases of wound healing is absent yet. The development of new topical drugs from photosynthetic microorganisms could be a potential alternative to maximize healing. KEY POINTS ⢠Conventional treatment to skin injuries has limitations. ⢠Proteins, terpenes, and phenols increase collagen deposition and re-epithelialization. ⢠Microalgae and cyanobacteria may be used as a source of biomolecules to wound healing.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Chlorella
/
Microalgas
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil