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Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification.
Yun, Jinyoung; Jeong, Yeonsu; Nam, Onyou; Yeo, Ki Baek; Jo, Yun Kee; Heo, Hye Ryoung; Kim, Chang Sup; Joo, Kye Il; Pack, Seung Pil; Jin, EonSeon; Cha, Hyung Joon.
Afiliación
  • Yun J; Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
  • Jeong Y; Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
  • Nam O; Department of Life Science, Hanyang University, Seoul 04763, Republic of Korea.
  • Yeo KB; Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea.
  • Jo YK; Department of Biomedical Convergence Science and Technology, Kyungpook National University, Daegu 41566, Republic of Korea.
  • Heo HR; Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
  • Kim CS; School of Chemistry and Biochemistry, Yeungnam University, Gyeongsan 38541, Republic of Korea.
  • Joo KI; Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
  • Pack SP; Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea.
  • Jin E; Department of Life Science, Hanyang University, Seoul 04763, Republic of Korea.
  • Cha HJ; Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
ACS Appl Bio Mater ; 4(8): 6046-6055, 2021 08 16.
Article en En | MEDLINE | ID: mdl-35006887
Bone graft materials have been mainly developed based on inorganic materials, including calcium phosphate. However, these graft materials usually act as osteoconductive rather than osteoinductive scaffolds. To improve bone reconstruction, a combination of several materials has been proposed. However, there are still no alternatives that can completely replace the existing animal-derived bone graft materials. In this work, a marine-inspired biomineral complex was suggested as a potential bone graft material. The proposed biosilicified coccolithophore-derived coccoliths using bioengineered mussel adhesive proteins show osteopromotive ability through the synergistic effects of osteoconductivity from calcium carbonate and osteoinductivity from silica. Its possibility of use as a bone substitute was determined by evaluating the in vitro osteogenic behaviors of multipotent mesenchymal stem cells and in vivo bone regeneration in a rat calvarial defect model. Therefore, the marine-inspired biomineral complex developed in this study could be successfully used for bone tissue engineering.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Regeneración Ósea / Sustitutos de Huesos Límite: Animals Idioma: En Revista: ACS Appl Bio Mater Año: 2021 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Regeneración Ósea / Sustitutos de Huesos Límite: Animals Idioma: En Revista: ACS Appl Bio Mater Año: 2021 Tipo del documento: Article