Burden of central nervous system complications in sickle cell disease: A systematic review and meta-analysis.
Pediatr Blood Cancer
; 69(4): e29493, 2022 04.
Article
en En
| MEDLINE
| ID: mdl-35038214
ABSTRACT
Sickle cell disease (SCD) patients are at high risk of central nervous system (CNS) complications and may experience significant morbidity. The study was conducted to describe the comprehensive burden of SCD-related CNS complications and to identify patient-reported outcome (PRO) instruments for future research. The review included 32 studies published from January 2000 to 2020, evaluating humanistic and economic outcomes. Twenty-three studies reported humanistic outcomes, 16 of which measured cognitive function using Wechsler Intelligence Scales. A meta-analysis was conducted, finding full-scale intelligence quotient (IQ) was significantly lower in overt stroke versus controls -12.6 (p < .001); silent cerebral infarct (SCI) versus controls -5.7 (p < .001); overt stroke versus SCI -9.4 (p = .008); and any event versus controls -7.6 (p < .001). This review quantified the cognitive deficits associated with CNS complications in pediatric SCD populations and highlights the need for improved prevention/treatment. As PRO evidence was limited, we discussed areas for future research.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Accidente Cerebrovascular
/
Anemia de Células Falciformes
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Límite:
Child
/
Humans
Idioma:
En
Revista:
Pediatr Blood Cancer
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos