Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at &#945;5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice.

Troppoli, Timothy A; Zanos, Panos; Georgiou, Polymnia; Gould, Todd D; Rudolph, Uwe; Thompson, Scott M

Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice.

Troppoli, Timothy A; Zanos, Panos; Georgiou, Polymnia; Gould, Todd D; Rudolph, Uwe; Thompson, Scott M.

Afiliación

Troppoli TA; Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland; Molecular Medicine Program, University of Maryland School of Medicine, Baltimore, Maryland.
Zanos P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
Georgiou P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.
Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland; Veterans Aff
Rudolph U; Department of Comparative Biosciences and Carl R Woese Institute for Genomic Biology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Thompson SM; Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: sthompson@som.umaryland.edu.

Biol Psychiatry ; 92(3): 216-226, 2022 08 01.

Article en En | MEDLINE | ID: mdl-35120711

Asunto(s)

Benzodiazepinas; Ketamina; Anhedonia; Animales; Benzodiazepinas/farmacología; Femenino; Humanos; Ketamina/farmacología; Masculino; Ratones; N-Metilaspartato; Receptores de GABA; Receptores de GABA-A/fisiología; Sacarosa; Ácido alfa-Amino-3-hidroxi-5-metil-4-isoxazol Propiónico; Ácido gamma-Aminobutírico

Palabras clave

Antidepressant; Depression; GABA; Gamma; Hippocampus; Ketamine

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Benzodiazepinas / Ketamina Límite: Animals / Female / Humans / Male Idioma: En Revista: Biol Psychiatry Año: 2022 Tipo del documento: Article

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