The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg.

McElroy, Dan L; Roebuck, Andrew J; Greba, Quentin; Garai, Sumanta; Brandt, Asher L; Yilmaz, Orhan; Cain, Stuart M; Snutch, Terrance P; Thakur, Ganesh A; Laprairie, Robert B; Howland, John G

McElroy, Dan L; Roebuck, Andrew J; Greba, Quentin; Garai, Sumanta; Brandt, Asher L; Yilmaz, Orhan; Cain, Stuart M; Snutch, Terrance P; Thakur, Ganesh A; Laprairie, Robert B; Howland, John G.

Afiliación

McElroy DL; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Roebuck AJ; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Greba Q; School of Liberal Arts, Yukon University, Whitehorse, YT Y1A 5K4, Canada.
Garai S; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Brandt AL; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States.
Yilmaz O; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Cain SM; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Snutch TP; Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Thakur GA; Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Laprairie RB; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States.
Howland JG; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.

IBRO Neurosci Rep ; 12: 121-130, 2022 Jun.

Article en En | MEDLINE | ID: mdl-35128516

Palabras clave

2-AG, 2-arachidonoylglycerol; AEA, anandamide; CAE, childhood absence epilepsy; CB1R, cannabinoid type-1 receptor; Childhood absence epilepsy; ECS, endocannabinoid system; EEG, electroencephalography; Electroencephalogram; Endocannabinoid system; GAERS; GAERS, Genetic Absence Epilepsy Rats from Strasbourg; LFP, local field potential; PAM, positive allosteric modulator; Positive allosteric modulator; SWD, spike and wave discharge; THC, Δ9-tetrahydrocannabinol; Type 1 cannabinoid receptor; ago-PAM, allosteric agonist and positive allosteric modulator

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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: IBRO Neurosci Rep Año: 2022 Tipo del documento: Article País de afiliación: Canadá

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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: IBRO Neurosci Rep Año: 2022 Tipo del documento: Article País de afiliación: Canadá