High dose folic acid treatment of fragile (X) males.
Am J Med Genet
; 23(1-2): 263-71, 1986.
Article
en En
| MEDLINE
| ID: mdl-3513568
ABSTRACT
We conducted an experimental trial of high-dose folic acid given to five males, ages 8 to 26 years, with the fra(X) syndrome. In this double blind study, each subject received 250 mg per day of folic acid for 3 months, followed by placebo for 3 months, and folic acid again for an additional three months. Based on IQ tests, behavior ratings, the Autistic Descriptors Checklist, and parental ratings, there was little evidence to suggest any positive effects seen during the administration of high-dose folic acid. Therefore, this study has provided little support for a hypothesis of benefit of high-dose folic acid in the treatment of the fra(X) syndrome.
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Base de datos:
MEDLINE
Asunto principal:
Aberraciones Cromosómicas Sexuales
/
Ácido Fólico
/
Síndrome del Cromosoma X Frágil
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Child
/
Humans
/
Male
Idioma:
En
Revista:
Am J Med Genet
Año:
1986
Tipo del documento:
Article