Coronary volume to left ventricular mass ratio in patients with diabetes mellitus.

Kuneman, Jurrien H; El Mahdiui, Mohammed; van Rosendael, Alexander R; van den Hoogen, Inge J; Patel, Manesh R; Nørgaard, Bjarne Linde; Fairbairn, Timothy A; Nieman, Koen; Akasaka, Takashi; Berman, Daniel S; Hurwitz Koweek, Lynne M; Pontone, Gianluca; Kawasaki, Tomohiro; Rønnow Sand, Niels Peter; Jensen, Jesper M; Amano, Tetsuya; Poon, Michael; Øvrehus, Kristian A; Sonck, Jeroen; Rabbat, Mark G; De Bruyne, Bernard; Rogers, Campbell; Matsuo, Hitoshi; Bax, Jeroen J; Leipsic, Jonathon A; Knuuti, Juhani

Kuneman, Jurrien H; El Mahdiui, Mohammed; van Rosendael, Alexander R; van den Hoogen, Inge J; Patel, Manesh R; Nørgaard, Bjarne Linde; Fairbairn, Timothy A; Nieman, Koen; Akasaka, Takashi; Berman, Daniel S; Hurwitz Koweek, Lynne M; Pontone, Gianluca; Kawasaki, Tomohiro; Rønnow Sand, Niels Peter; Jensen, Jesper M; Amano, Tetsuya; Poon, Michael; Øvrehus, Kristian A; Sonck, Jeroen; Rabbat, Mark G; De Bruyne, Bernard; Rogers, Campbell; Matsuo, Hitoshi; Bax, Jeroen J; Leipsic, Jonathon A; Knuuti, Juhani.

Afiliación

Kuneman JH; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
El Mahdiui M; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
van Rosendael AR; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
van den Hoogen IJ; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Patel MR; Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Nørgaard BL; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Fairbairn TA; Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom.
Nieman K; Departments of Cardiovascular Medicine and Radiology, Stanford University, Stanford, CA, USA.
Akasaka T; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
Berman DS; Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
Hurwitz Koweek LM; Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Pontone G; Centro Cardiologico Monzino, Milan, Italy.
Kawasaki T; Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan.
Rønnow Sand NP; Department of Cardiology, Odense University Hospital, Odense, Esbjerg, Denmark.
Jensen JM; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Amano T; Department of Cardiology, Aichi Medical University, Aichi, Japan.
Poon M; Department of Noninvasive Cardiac Imaging, Northwell Health, New York, USA.
Øvrehus KA; Department of Cardiology, Odense University Hospital, Odense, Esbjerg, Denmark.
Sonck J; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Rabbat MG; Division of Cardiology, Loyola University Chicago, Chicago, IL, USA.
De Bruyne B; Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.
Rogers C; HeartFlow Inc., Redwood City, CA, USA.
Matsuo H; Department of Cardiovascular Medicine, Gifu Heart Center, Gifu, Japan.
Bax JJ; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Leipsic JA; Department of Radiology, St Paul's Hospital, Vancouver, British Columbia, Canada.
Knuuti J; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Turku PET Center, Turku University Hospital and University of Turku, Turku, Finland. Electronic address: juhani.knuuti@tyks.fi.

J Cardiovasc Comput Tomogr ; 16(4): 319-326, 2022.

Article en En | MEDLINE | ID: mdl-35190274

ABSTRACT

ABSTRACT

BACKGROUND:

Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes.

METHODS:

Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes.

RESULTS:

Of the 3053 patients (age 66 â± â10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 â± â940 âmm3 vs. 3040 â± â970 âmm3, p â< â0.0001), whereas the myocardial mass was comparable between the 2 groups (122 â± â33 âg vs. 122 â± â32 âg, p â= â0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 â± â6.8 âmm3/g vs. 25.7 â± â7.5 âmm3/g, p â< â0.0001). Among subjects with obstructive CAD (n â= â2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 â± â6.7 âmm3/g vs. 25.0 â± â7.3 âmm3/g, p â< â0.0001 and 25.6 â± â6.9 âmm3/g vs. 27.3 â± â7.6 âmm3/g, respectively, p â= â0.006).

CONCLUSION:

The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.

Asunto(s)

Enfermedad de la Arteria Coronaria; Estenosis Coronaria; Diabetes Mellitus; Anciano; Angiografía por Tomografía Computarizada; Angiografía Coronaria/métodos; Enfermedad de la Arteria Coronaria/diagnóstico por imagen; Enfermedad de la Arteria Coronaria/terapia; Diabetes Mellitus/diagnóstico; Femenino; Humanos; Masculino; Persona de Mediana Edad; Valor Predictivo de las Pruebas

Palabras clave

Coronary artery disease; Coronary computed tomography angiography; Coronary volume; Diabetes mellitus; Left ventricular mass; Volume to mass ratio

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Estenosis Coronaria / Diabetes Mellitus Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiovasc Comput Tomogr Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / RADIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos

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