Coronary volume to left ventricular mass ratio in patients with diabetes mellitus.
J Cardiovasc Comput Tomogr
; 16(4): 319-326, 2022.
Article
en En
| MEDLINE
| ID: mdl-35190274
ABSTRACT
BACKGROUND:
Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes.METHODS:
Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes.RESULTS:
Of the 3053 patients (age 66 â± â10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 â± â940 âmm3 vs. 3040 â± â970 âmm3, p â< â0.0001), whereas the myocardial mass was comparable between the 2 groups (122 â± â33 âg vs. 122 â± â32 âg, p â= â0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 â± â6.8 âmm3/g vs. 25.7 â± â7.5 âmm3/g, p â< â0.0001). Among subjects with obstructive CAD (n â= â2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 â± â6.7 âmm3/g vs. 25.0 â± â7.3 âmm3/g, p â< â0.0001 and 25.6 â± â6.9 âmm3/g vs. 27.3 â± â7.6 âmm3/g, respectively, p â= â0.006).CONCLUSION:
The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Estenosis Coronaria
/
Diabetes Mellitus
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Cardiovasc Comput Tomogr
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
RADIOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Países Bajos