PTEN/PI3K/Akt pathway alters sensitivity of T-cell acute lymphoblastic leukemia to L-asparaginase.

Hlozkova, Katerina; Hermanova, Ivana; Safrhansova, Lucie; Alquezar-Artieda, Natividad; Kuzilkova, Daniela; Vavrova, Adela; Sperkova, Kristyna; Zaliova, Marketa; Stary, Jan; Trka, Jan; Starkova, Julia

Hlozkova, Katerina; Hermanova, Ivana; Safrhansova, Lucie; Alquezar-Artieda, Natividad; Kuzilkova, Daniela; Vavrova, Adela; Sperkova, Kristyna; Zaliova, Marketa; Stary, Jan; Trka, Jan; Starkova, Julia.

Afiliación

Hlozkova K; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.
Hermanova I; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Safrhansova L; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.
Alquezar-Artieda N; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Kuzilkova D; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.
Vavrova A; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Sperkova K; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.
Zaliova M; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Stary J; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.
Trka J; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Starkova J; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.

Sci Rep ; 12(1): 4043, 2022 03 08.

Article en En | MEDLINE | ID: mdl-35260738

Asunto(s)

Asparaginasa; Fosfohidrolasa PTEN; Fosfatidilinositol 3-Quinasas; Leucemia-Linfoma Linfoblástico de Células T Precursoras; Asparaginasa/farmacología; Asparaginasa/uso terapéutico; Niño; Humanos; Fosfohidrolasa PTEN/genética; Fosfohidrolasa PTEN/metabolismo; Fosfatidilinositol 3-Quinasas/genética; Fosfatidilinositol 3-Quinasas/metabolismo; Leucemia-Linfoma Linfoblástico de Células T Precursoras/tratamiento farmacológico; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Transducción de Señal; Linfocitos T/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Asparaginasa / Fosfatidilinositol 3-Quinasas / Fosfohidrolasa PTEN / Leucemia-Linfoma Linfoblástico de Células T Precursoras Tipo de estudio: Diagnostic_studies Límite: Child / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: República Checa

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