Unraveling the role of the microbiome in chronic rhinosinusitis.
J Allergy Clin Immunol
; 149(5): 1513-1521, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-35300985
ABSTRACT
Chronic rhinosinusitis (CRS) is a complex, heterogenous condition that is likely associated with infectious and inflammatory causative factors. Renewed interest in the role that microbes play in this condition has stemmed from advancements in microbe identification and parallel research implicating the microbiome as having a role in other chronic inflammatory conditions. This clinical commentary provides a review of the current literature relevant to chronic rhinosinusitis. Particular focus is placed on factors specific to investigation of the sinonasal microbiome, evidence for the role of dysbiosis in the disease state, and influences that may affect the microbiome. Possible mechanisms of disease and therapeutic implications through microbial manipulation are also reviewed, as are deficiencies and limitations of the current body of research.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sinusitis
/
Rinitis
/
Microbiota
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Allergy Clin Immunol
Año:
2022
Tipo del documento:
Article