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Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting.
Isler, Burcu; Özer, Berna; Çinar, Güle; Aslan, Abdullah Tarik; Vatansever, Cansel; Falconer, Caitlin; Dolapçi, Istar; Simsek, Funda; Tülek, Necla; Demirkaya, Hamiyet; Menekse, Sirin; Akalin, Halis; Balkan, Ilker Inanç; Aydin, Mehtap; Tigen, Elif Tükenmez; Demir, Safiye Koçulu; Kapmaz, Mahir; Keske, Siran; Dogan, Özlem; Arabaci, Çigdem; Yagci, Serap; Hazirolan, Gülsen; Bakir, Veli Oguzalp; Gönen, Mehmet; Chatfield, Mark D; Forde, Brian; Saltoglu, Nese; Azap, Alpay; Azap, Özlem; Akova, Murat; Paterson, David L; Can, Füsun; Ergönül, Önder.
Afiliación
  • Isler B; Centre for Clinical Research, University of Queensland, Brisbane, Australia.
  • Özer B; Clinical Microbiology, School of Medicine, Koç University, Istanbul, Turkey.
  • Çinar G; Infectious Diseases and Clinical Microbiology, Ankara University School of Medicine, Ankara, Turkey.
  • Aslan AT; Infectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey.
  • Vatansever C; Clinical Microbiology, School of Medicine, Koç University, Istanbul, Turkey.
  • Falconer C; Centre for Clinical Research, University of Queensland, Brisbane, Australia.
  • Dolapçi I; Clinical Microbiology, Ankara University School of Medicine, Ankara, Turkey.
  • Simsek F; Infectious Diseases and Clinical Microbiology, University of Health Sciences, Ministry of Health Prof Dr Cemil Tasçioglu City Hospital, Istanbul, Turkey.
  • Tülek N; Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Atilim University, Ankara, Turkey.
  • Demirkaya H; Infectious Diseases and Clinical Microbiology, Baskent University, Ankara Hospital, Ankara, Turkey.
  • Menekse S; Infectious Diseases, Kosuyolu Kartal Heart Training and Research Hospital, Istanbul, Turkey.
  • Akalin H; Infectious Diseases and Clinical Microbiology, Uludag University School of Medicine, Bursa, Turkey.
  • Balkan II; Infectious Diseases and Clinical Microbiology, School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Aydin M; Infectious Diseases and Clinical Microbiology, Ümraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Tigen ET; Infectious Diseases and Clinical Microbiology, Marmara University, Pendik Training and Research Hospital, Istanbul, Turkey.
  • Demir SK; Infectious Diseases and Clinical Microbiology, Demiroglu Bilim University, Istanbul, Turkey.
  • Kapmaz M; Infectious Diseases and Clinical Microbiology, Koç University Hospital, Istanbul, Turkey.
  • Keske S; Infectious Diseases, School of Medicine, Koç University, Rumelifeneri, 34450, Sariyer, Istanbul, Turkey.
  • Dogan Ö; Koç University Is Bank Centre for Infectious Diseases (KUISCID), Istanbul, Turkey.
  • Arabaci Ç; Clinical Microbiology, School of Medicine, Koç University, Istanbul, Turkey.
  • Yagci S; Clinical Microbiology, University of Health Sciences, Ministry of Health Prof Dr Cemil Tasçioglu City Hospital, Istanbul, Turkey.
  • Hazirolan G; Clinical Microbiology, Ankara Training and Research Hospital, Ankara, Turkey.
  • Bakir VO; Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey.
  • Gönen M; Graduate School of Sciences and Engineering, Koç University, Istanbul, Turkey.
  • Chatfield MD; Industrial Engineering, College of Engineering, Koç University, Istanbul, Turkey.
  • Forde B; Infectious Diseases, School of Medicine, Koç University, Rumelifeneri, 34450, Sariyer, Istanbul, Turkey.
  • Saltoglu N; Centre for Clinical Research, University of Queensland, Brisbane, Australia.
  • Azap A; Centre for Clinical Research, University of Queensland, Brisbane, Australia.
  • Azap Ö; Infectious Diseases and Clinical Microbiology, School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Akova M; Infectious Diseases and Clinical Microbiology, Ankara University School of Medicine, Ankara, Turkey.
  • Paterson DL; Infectious Diseases and Clinical Microbiology, Baskent University, Ankara Hospital, Ankara, Turkey.
  • Can F; Infectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey.
  • Ergönül Ö; Centre for Clinical Research, University of Queensland, Brisbane, Australia.
Eur J Clin Microbiol Infect Dis ; 41(5): 841-847, 2022 May.
Article en En | MEDLINE | ID: mdl-35301623
ABSTRACT
A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Infecciones por Klebsiella / Sepsis Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Infecciones por Klebsiella / Sepsis Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Australia