Aminoacylation of Indole Diterpenes by Cluster-Specific Monomodular NRPS-like Enzymes.
Org Lett
; 24(12): 2332-2337, 2022 04 01.
Article
en En
| MEDLINE
| ID: mdl-35315670
ABSTRACT
Decoration of the core scaffolds of indole diterpene (IDT) natural products is key to generating structural and bioactivity diversity. Aminoacylation as a tailoring step is rarely linked to terpene biosynthesis and is extremely rare in IDT biosynthesis. Through heterologous pathway reconstruction, we have illuminated the genetic and biochemical basis for the only reported examples of aminoacylation in IDT biosynthesis, demonstrating the unusual involvement of monomodular nonribosomal peptide synthetase (NRPS)-like enzymes in IDT decoration.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Péptido Sintasas
/
Diterpenos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda