Non-Kolbe electrolysis of N-protected-α-amino acids: a standardized method for the synthesis of N-protected (1-methoxyalkyl)amines.
RSC Adv
; 12(4): 2107-2114, 2022 Jan 12.
Article
en En
| MEDLINE
| ID: mdl-35425224
ABSTRACT
Here, we report a standardized method for the synthesis of N-protected (1-methoxyalkyl)amines by the electrochemical decarboxylative α-methoxylation of α-amino acid derivatives using the commercially available, easy-to-use, compact ElectraSyn 2.0 setup. The use of equipment with a standardized power source, electrodes, and other accessories allows this experimental procedure to be easily transferred to any laboratory in the world. A simple workup and chromatography-free purification produced the products in excellent yields above 90%.
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RSC Adv
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2022
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Article