The Genetic Evolution of Metastasis.
Cancer Res
; 82(10): 1849-1857, 2022 05 16.
Article
en En
| MEDLINE
| ID: mdl-35476646
ABSTRACT
Cancer is an evolutionary process that is characterized by the emergence of multiple genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity provides a substrate for the selection of adaptive clones, such as those that lead to metastasis. Comparative molecular studies of primary tumors and metastases have identified distinct genomic features associated with the development of metastases. In this review, we discuss how these insights could inform clinical decision-making and uncover rational antimetastasis treatment strategies.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido