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Effects of a New Antithrombotic Drug GRS, a Soluble Guanylate Cyclase Stimulator, on Endothelial Dysfunction in Rats with Myocardial Infarction.
Bykov, V V; Smol'yakova, V I; Chernysheva, G A; Aliev, O I; Anishchenko, A M; Sidekhmenova, A V; Dunaeva, O I; Stankevich, S A; Khazanov, V A.
Afiliación
  • Bykov VV; LLC Innovative Pharmacology Research, Tomsk, Russia. vladimir.b.1989@gmail.com.
  • Smol'yakova VI; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia. vladimir.b.1989@gmail.com.
  • Chernysheva GA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Aliev OI; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Anishchenko AM; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Sidekhmenova AV; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
  • Dunaeva OI; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Stankevich SA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Khazanov VA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Bull Exp Biol Med ; 172(6): 709-712, 2022 Apr.
Article en En | MEDLINE | ID: mdl-35501639
New antithrombotic drug GRS, a soluble guanylate cyclase stimulator, after repeated administration in a dose of 10 mg/kg alleviates the symptoms of endothelial dysfunction in rats with myocardial infarction; it restores antiplatelet activity of the blood vessel wall and vasodilatory function of the endothelium without producing significant effect on endothelium-independent vasodilation. GRS also has direct antiaggregant and antihypertensive effects in therapeutic doses. The obtained data suggest that GRS can be therapeutically useful in patients with cardiovascular diseases accompanied by endothelial dysfunction.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Guanilato Ciclasa / Infarto del Miocardio Límite: Animals / Humans Idioma: En Revista: Bull Exp Biol Med Año: 2022 Tipo del documento: Article País de afiliación: Rusia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Guanilato Ciclasa / Infarto del Miocardio Límite: Animals / Humans Idioma: En Revista: Bull Exp Biol Med Año: 2022 Tipo del documento: Article País de afiliación: Rusia