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New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins.
Jung, Sascha; Fuchs, Natalie; Grathwol, Christoph; Hellmich, Ute A; Wagner, Annika; Diehl, Erika; Willmes, Thomas; Sotriffer, Christoph; Schirmeister, Tanja.
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  • Jung S; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudingerweg 5, Mainz, 55128, Germany.
  • Fuchs N; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudingerweg 5, Mainz, 55128, Germany.
  • Grathwol C; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, Karlsruhe, 76131, Germany.
  • Hellmich UA; Department of Chemistry, Biochemistry Section, Johannes Gutenberg University, Hanns-Dieter-Hüsch-Weg 17, Mainz, 55128, Germany; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University, Max-von-Laue-Str. 9, Frankfurt, 60438, Germany.
  • Wagner A; Department of Chemistry, Biochemistry Section, Johannes Gutenberg University, Hanns-Dieter-Hüsch-Weg 17, Mainz, 55128, Germany.
  • Diehl E; Department of Chemistry, Biochemistry Section, Johannes Gutenberg University, Hanns-Dieter-Hüsch-Weg 17, Mainz, 55128, Germany.
  • Willmes T; Institute of Pharmacy and Food Chemistry, University Würzburg, Am Hubland, Würzburg, 97074, Germany.
  • Sotriffer C; Institute of Pharmacy and Food Chemistry, University Würzburg, Am Hubland, Würzburg, 97074, Germany.
  • Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudingerweg 5, Mainz, 55128, Germany. Electronic address: schirmei@uni-mainz.de.
Eur J Med Chem ; 238: 114460, 2022 Aug 05.
Article en En | MEDLINE | ID: mdl-35597010
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tripanocidas / Trypanosoma brucei brucei / Tripanosomiasis Africana / Peptidomiméticos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tripanocidas / Trypanosoma brucei brucei / Tripanosomiasis Africana / Peptidomiméticos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Alemania