Cerebral Sinus Venous Thrombosis in Infants after Surgery for Congenital Heart Disease.
J Pediatr
; 248: 59-65.e3, 2022 09.
Article
en En
| MEDLINE
| ID: mdl-35667448
ABSTRACT
OBJECTIVE:
To determine the prevalence of and risk factors for cerebral sinus venous thrombosis (CSVT) in neonates undergoing congenital heart disease (CHD) repair. STUDYDESIGN:
Neonates who had CHD repair with cardiopulmonary bypass and postoperative brain magnetic resonance imaging (MRI) between 2013 and 2019 at a single tertiary care center were identified from institutional databases. Demographic, clinical, and surgical data were abstracted from these databases and from the medical record; 278 neonates with CHD had cardiopulmonary bypass, 184 of whom had a postoperative brain MRI.RESULTS:
Eight patients (4.3%) had a CSVT. Transposition of the great arteries with an intact ventricular septum (P < .01) and interrupted aortic arch (P = .02) were associated with an increased risk for CSVT. Other risk factors for CSVT included cross-clamp time (98 [IQR, 77.5-120] minutes vs 67 [IQR, 44-102] minutes; P = .03), units of platelets (3.63 [IQR, 3-4] vs 2.17 [IQR, 1-4]; P < .01) and packed red blood cells (0.81 [IQR, 0.25-1] vs 1.21 [IQR, 1-1]; P = .03) transfused intraoperatively, and time between surgery and MRI (10 [IQR, 7-12.5] days vs 20 [IQR, 12-35] days; P < .01). Five patients (62.5%) were treated with anticoagulation. All patients had complete or partial resolution of their CSVT, regardless of treatment.CONCLUSIONS:
Brain MRI after cardiopulmonary bypass in neonates revealed a low prevalence of CSVT (4.3%). Further studies are needed to establish best practices for surveillance, prevention, and treatment of CSVT in this population.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trombosis de los Senos Intracraneales
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Transposición de los Grandes Vasos
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Trombosis de la Vena
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Cardiopatías Congénitas
Tipo de estudio:
Etiology_studies
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Guideline
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
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Infant
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Newborn
Idioma:
En
Revista:
J Pediatr
Año:
2022
Tipo del documento:
Article