Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss.

Ikeuchi, Tomoko; Moutsopoulos, Niki M

Ikeuchi, Tomoko; Moutsopoulos, Niki M.

Afiliación

Ikeuchi T; Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 9000 Rockville Pike, 30 convent Dr, Bldg30, Room 327, Bethesda, MD 20892, United States of America. Electronic address: tomoko.ikeuchi@nih.gov.
Moutsopoulos NM; Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 9000 Rockville Pike, 30 convent Dr, Bldg30, Room 327, Bethesda, MD 20892, United States of America. Electronic address: nmoutsop@mail.nih.gov.

Bone ; 163: 116500, 2022 10.

Article en En | MEDLINE | ID: mdl-35870792

ABSTRACT

ABSTRACT

Periodontitis is a prevalent human disease of inflammation-induced bone destruction. Through studies in patient lesions of rare and common forms of periodontitis and animal model experimentation, Th17/IL-17 related immune pathways have emerged as mediators of disease pathology. In this focused review, we examine mechanisms of induction, amplification and pathogenicity of Th17 cells in periodontitis.

Asunto(s)

Pérdida de Hueso Alveolar; Periodontitis; Animales; Modelos Animales de Enfermedad; Humanos; Inflamación; Interleucina-17; Células Th17

Palabras clave

Bone loss; Oral microbiome; Osteoimmunology; Periodontitis; Th17 cells

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Periodontitis / Pérdida de Hueso Alveolar Límite: Animals / Humans Idioma: En Revista: Bone Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2022 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google