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A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder.
Galaj, Ewa; Bi, Guo-Hua; Klein, Benjamin; Hempel, Briana; Shaik, Anver Basha; Gogarnoiu, Emma S; Friedman, Jacob; Lam, Jenny; Rais, Rana; Reed, John F; Bloom, Shelley H; Swanson, Tracy L; Schmachtenberg, Jennifer L; Eshleman, Amy J; Janowsky, Aaron; Xi, Zheng-Xiong; Newman, Amy Hauck.
Afiliación
  • Galaj E; Medicinal Chemistry Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
  • Bi GH; Department of Psychological and Brain Sciences, Colgate University, Hamilton, NY, USA.
  • Klein B; Medicinal Chemistry Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
  • Hempel B; Medicinal Chemistry Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
  • Shaik AB; Medicinal Chemistry Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
  • Gogarnoiu ES; Medicinal Chemistry Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
  • Friedman J; Medicinal Chemistry Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
  • Lam J; Medicinal Chemistry Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
  • Rais R; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
  • Reed JF; Medicinal Chemistry Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD, USA.
  • Bloom SH; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
  • Swanson TL; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
  • Schmachtenberg JL; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
  • Eshleman AJ; Research Service, VA Portland Health Care System, Portland, OR, USA.
  • Janowsky A; Research Service, VA Portland Health Care System, Portland, OR, USA.
  • Xi ZX; Research Service, VA Portland Health Care System, Portland, OR, USA.
  • Newman AH; Research Service, VA Portland Health Care System, Portland, OR, USA.
Neuropsychopharmacology ; 47(13): 2309-2318, 2022 12.
Article en En | MEDLINE | ID: mdl-35879349
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores de Dopamina D3 / Trastornos Relacionados con Opioides Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Neuropsychopharmacology Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores de Dopamina D3 / Trastornos Relacionados con Opioides Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Neuropsychopharmacology Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos