Respiratory chain dysfunction in perifascicular muscle fibres in patients with dermatomyositis is associated with mitochondrial DNA depletion.

Hedberg-Oldfors, Carola; Lindgren, Ulrika; Visuttijai, Kittichate; Lööf, Daniel; Roos, Sara; Thomsen, Christer; Oldfors, Anders

Hedberg-Oldfors, Carola; Lindgren, Ulrika; Visuttijai, Kittichate; Lööf, Daniel; Roos, Sara; Thomsen, Christer; Oldfors, Anders.

Afiliación

Hedberg-Oldfors C; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Lindgren U; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Visuttijai K; Neuromuscular Center, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Lööf D; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Roos S; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Thomsen C; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Oldfors A; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Neuropathol Appl Neurobiol ; 48(7): e12841, 2022 12.

Article en En | MEDLINE | ID: mdl-35894812

Asunto(s)

Deficiencia de Citocromo-c Oxidasa; Dermatomiositis; Adulto; Humanos; Deficiencia de Citocromo-c Oxidasa/metabolismo; Deficiencia de Citocromo-c Oxidasa/patología; Succinato Deshidrogenasa/análisis; Succinato Deshidrogenasa/metabolismo; Dermatomiositis/patología; Transporte de Electrón; Fibras Musculares Esqueléticas/química; Fibras Musculares Esqueléticas/metabolismo; Fibras Musculares Esqueléticas/patología; ADN Mitocondrial/genética; Complejo IV de Transporte de Electrones/análisis; Complejo IV de Transporte de Electrones/genética; Complejo IV de Transporte de Electrones/metabolismo; Músculo Esquelético/patología

Palabras clave

dermatomyositis; inflammatory myopathy; mitochondria; mitochondrial DNA; oxidative phosphorylation; respiratory chain

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Deficiencia de Citocromo-c Oxidasa / Dermatomiositis Tipo de estudio: Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Neuropathol Appl Neurobiol Año: 2022 Tipo del documento: Article País de afiliación: Suecia

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