Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle.
Eur Respir Rev
; 31(165)2022 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-35896274
ABSTRACT
Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has been considered primarily as a manifestation of cellular immune responses. However, in reality, an array of complex, interacting and multifactorial mechanisms contribute to its emergence. Alloimmune-dependent mechanisms, including T-cell-mediated rejection and antibody-mediated rejection, as well as non-alloimmune injuries, have been implicated. Moreover, a role has emerged for autoimmune responses to lung self-antigens in the development of chronic graft injury. The aim of this review is to summarise the immune processes involved in the pathogenesis of chronic lung allograft dysfunction, with advanced insights into the role of innate immune pathways and crosstalk between innate and adaptive immunity, and to identify gaps in current knowledge.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Pulmón
/
Rechazo de Injerto
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Eur Respir Rev
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido