Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury.

Miyamoto, Hiroko Deguchi; Ikeda, Masataka; Ide, Tomomi; Tadokoro, Tomonori; Furusawa, Shun; Abe, Ko; Ishimaru, Kosei; Enzan, Nobuyuki; Sada, Masashi; Yamamoto, Taishi; Matsushima, Shouji; Koumura, Tomoko; Yamada, Ken-Ichi; Imai, Hirotaka; Tsutsui, Hiroyuki

Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury.

Miyamoto, Hiroko Deguchi; Ikeda, Masataka; Ide, Tomomi; Tadokoro, Tomonori; Furusawa, Shun; Abe, Ko; Ishimaru, Kosei; Enzan, Nobuyuki; Sada, Masashi; Yamamoto, Taishi; Matsushima, Shouji; Koumura, Tomoko; Yamada, Ken-Ichi; Imai, Hirotaka; Tsutsui, Hiroyuki.

Afiliación

Miyamoto HD; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ikeda M; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ide T; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tadokoro T; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Furusawa S; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Abe K; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ishimaru K; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Enzan N; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sada M; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yamamoto T; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Matsushima S; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Koumura T; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yamada KI; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Imai H; Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tsutsui H; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

JACC Basic Transl Sci ; 7(8): 800-819, 2022 Aug.

Article en En | MEDLINE | ID: mdl-36061338

Palabras clave

AMI, acute myocardial infarction; CsA, cyclosporine A; CypD, cyclophilin D; DXZ, dexrazoxane; ER, endoplasmic reticulum; Fer-1, ferrostatin-1; GPx4, glutathione peroxidase 4; H/R, hypoxia-reoxygenation; HF, heart failure; HO-1, heme oxygenase 1; I/R, ischemia-reperfusion; LP, lipid peroxide; MPT, mitochondrial permeability transition; MPT-driven necrosis; RCD, regulated cell death; STEMI, ST-segment elevation myocardial infarction; cyclosporine A; ferroptosis; glutathione peroxidase 4; ischemia-reperfusion injury

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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: Japón

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: Japón