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Atropine Is a Suppressor of Epithelial-Mesenchymal Transition (EMT) That Reduces Stemness in Drug-Resistant Breast Cancer Cells.
Ahmed, Emad A; Alkuwayti, Mayyadah A; Ibrahim, Hairul-Islam M.
Afiliación
  • Ahmed EA; Biological Sciences Department, College of Science, King Faisal University, Al Ahsa 31982, Saudi Arabia.
  • Alkuwayti MA; Lab of Molecular Physiology, Zoology Department, Faculty of Science, Assiut University, Assiut 71515, Egypt.
  • Ibrahim HM; Biological Sciences Department, College of Science, King Faisal University, Al Ahsa 31982, Saudi Arabia.
Int J Mol Sci ; 23(17)2022 Aug 30.
Article en En | MEDLINE | ID: mdl-36077256
ABSTRACT
Atropine (ATR) is extracted from a belladonna plant that belongs to a class of anticholinergic drugs and is therefore involved in the treatment of the overdose of cholinergic drugs or mushroom poisoning. It is a well-known blocker of muscarinic acetylcholine receptors (mAChRs) that are expressed in various tumor cells, including breast tumors from animal and human origin, but it has yet to be recommended as an anticancer drug. Our in silico docking analysis indicates that atropine has a roust virtual binding, with a stable binding energy, to two major signaling molecules involved in EMT regulation E-cad and ZEB-2. For both, the gene and the protein expression level results show that atropine is an effective molecule in reducing epithelial-mesenchymal transition (EMT) and colony formation induced by TGF-B or carboplatin in both the mesenchymal-like cell line MDA-MB-231 and the epithelial-like cell line T47D. We conclude that atropine as a potential suppressor of EMT could be co-administrated with other chemotherapeutic drugs to reduce stemness in drug-resistant breast tumor cells.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Transición Epitelial-Mesenquimal Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Arabia Saudita

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Transición Epitelial-Mesenquimal Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Arabia Saudita