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Anti-inflammatory effects of ruxolitinib on chronic neutrophilic leukemia harboring CSF3R-T618I mutation with bilateral renal abscesses.
Sahara, Naohi; Yokoyama, Kazuaki; Matsunaga, Takashi; Kitahara, Shinsuke; Fujii, Tomoki; Kobayashi, Seiichiro; Yusa, Nozomi; Shimizu, Eigo; Imoto, Seiya; Tojo, Arinobu; Ohno, Nobuhiro.
Afiliación
  • Sahara N; Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan.
  • Yokoyama K; Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan.
  • Matsunaga T; Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan.
  • Kitahara S; Department of Clinical Oncology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, Kawasaki city, 211-8510 Kanagawa, Japan.
  • Fujii T; Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan.
  • Kobayashi S; Department of Clinical Oncology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, Kawasaki city, 211-8510 Kanagawa, Japan.
  • Yusa N; Department of Hematology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Nakahara-ku, 211-8510 Kawasaki city, Kanagawa, Japan.
  • Shimizu E; Department of Applied Genomics, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan.
  • Imoto S; Health Intelligence Center, Institute of Medical Science, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan.
  • Tojo A; Health Intelligence Center, Institute of Medical Science, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan.
  • Ohno N; Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639 Tokyo, Japan.
Leuk Res Rep ; 18: 100348, 2022.
Article en En | MEDLINE | ID: mdl-36119729
ABSTRACT
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) characterized by sustained mature neutrophilic leukocytosis. Recently, presence of colony-stimulating factor 3 receptor (CSF3R) mutations has been added to the diagnostic criteria for CNL. Anti-inflammatory effects of the JAK1/2 inhibitor ruxolitinib relieve constitutional symptoms associated with MPN, such as fatigue, night sweats, and fever. We present a case of CNL harboring CSF3R-T618I mutation exacerbated by concomitant bilateral renal abscesses, which was refractory to antibiotics, at the time of initial diagnosis. In this case, ruxolitinib rapidly improved not only CNL but the infection, due to its anti-inflammatory potency.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Leuk Res Rep Año: 2022 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Leuk Res Rep Año: 2022 Tipo del documento: Article País de afiliación: Japón