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Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.
Bou Sleiman, Maroun; Roy, Suheeta; Gao, Arwen W; Sadler, Marie C; von Alvensleben, Giacomo V G; Li, Hao; Sen, Saunak; Harrison, David E; Nelson, James F; Strong, Randy; Miller, Richard A; Kutalik, Zoltán; Williams, Robert W; Auwerx, Johan.
Afiliación
  • Bou Sleiman M; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
  • Roy S; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38163, USA.
  • Gao AW; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
  • Sadler MC; Institute of Primary Care and Public Health (Unisante), University of Lausanne, Lausanne 1011, Switzerland.
  • von Alvensleben GVG; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
  • Li H; Department of Computational Biology, University of Lausanne, Lausanne 1015, Switzerland.
  • Sen S; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
  • Harrison DE; Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
  • Nelson JF; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Strong R; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • Miller RA; Barshop Center for Longevity Studies at the University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
  • Kutalik Z; Barshop Center for Longevity Studies at the University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
  • Williams RW; South Texas Veterans Healthcare System, San Antonio, TX 78229, USA.
  • Auwerx J; Department of Pathology, University of Michigan Geriatrics Center, Ann Arbor, MI 48109-2200, USA.
Science ; 377(6614): eabo3191, 2022 09 30.
Article en En | MEDLINE | ID: mdl-36173858
ABSTRACT
DNA variants that modulate life span provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-independent quantitative trait locus (QTL) on chromosome 12 and identified sex-specific QTLs, some of which we detected only in older mice. Similar relations between life history and longevity were uncovered in mice and humans, underscoring the importance of early access to nutrients and early growth. We identified common age- and sex-specific genetic effects on gene expression that we integrated with model organism and human data to create a hypothesis-building interactive resource of prioritized longevity and body weight genes. Finally, we validated Hipk1, Ddost, Hspg2, Fgd6, and Pdk1 as conserved longevity genes using Caenorhabditis elegans life-span experiments.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sitios de Carácter Cuantitativo / Longevidad Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Science Año: 2022 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sitios de Carácter Cuantitativo / Longevidad Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Science Año: 2022 Tipo del documento: Article País de afiliación: Suiza