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Stroke genetics informs drug discovery and risk prediction across ancestries.
Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi; Posner, Daniel C; Kamanu, Frederick K; Koido, Masaru; Le Grand, Quentin; Shi, Mingyang; He, Yunye; Georgakis, Marios K; Caro, Ilana; Krebs, Kristi; Liaw, Yi-Ching; Vaura, Felix C; Lin, Kuang; Winsvold, Bendik Slagsvold; Srinivasasainagendra, Vinodh; Parodi, Livia; Bae, Hee-Joon; Chauhan, Ganesh; Chong, Michael R; Tomppo, Liisa; Akinyemi, Rufus; Roshchupkin, Gennady V; Habib, Naomi; Jee, Yon Ho; Thomassen, Jesper Qvist; Abedi, Vida; Cárcel-Márquez, Jara; Nygaard, Marianne; Leonard, Hampton L; Yang, Chaojie; Yonova-Doing, Ekaterina; Knol, Maria J; Lewis, Adam J; Judy, Renae L; Ago, Tetsuro; Amouyel, Philippe; Armstrong, Nicole D; Bakker, Mark K; Bartz, Traci M; Bennett, David A; Bis, Joshua C; Bordes, Constance; Børte, Sigrid; Cain, Anael; Ridker, Paul M; Cho, Kelly.
Afiliación
  • Mishra A; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.
  • Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Hachiya T; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
  • Jürgenson T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Namba S; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia.
  • Posner DC; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
  • Kamanu FK; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
  • Koido M; TIMI Study Group, Boston, MA, USA.
  • Le Grand Q; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Shi M; Division of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan.
  • He Y; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Georgakis MK; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.
  • Caro I; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Krebs K; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Liaw YC; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Vaura FC; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Lin K; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Winsvold BS; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France.
  • Srinivasasainagendra V; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Parodi L; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
  • Bae HJ; Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan.
  • Chauhan G; Department of Internal Medicine, University of Turku, Turku, Finland.
  • Chong MR; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Turku, Finland.
  • Tomppo L; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Akinyemi R; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
  • Roshchupkin GV; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
  • Habib N; Department of Neurology, Oslo University Hospital, Oslo, Norway.
  • Jee YH; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Thomassen JQ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Abedi V; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Cárcel-Márquez J; Department of Neurology and Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
  • Nygaard M; Rajendra Institute of Medical Sciences, Ranchi, India.
  • Leonard HL; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
  • Yang C; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Yonova-Doing E; Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Knol MJ; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
  • Lewis AJ; Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
  • Judy RL; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Ago T; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Amouyel P; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Armstrong ND; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Bakker MK; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Bartz TM; Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA, USA.
  • Bennett DA; Department of Public Health Sciences, College of Medicine, The Pennsylvania State University, State College, PA, USA.
  • Bis JC; Stroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
  • Bordes C; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Børte S; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Cain A; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
  • Ridker PM; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
  • Cho K; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Nature ; 611(7934): 115-123, 2022 11.
Article en En | MEDLINE | ID: mdl-36180795
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Descubrimiento de Drogas / Accidente Cerebrovascular Isquémico Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans País/Región como asunto: Africa / Asia / Europa Idioma: En Revista: Nature Año: 2022 Tipo del documento: Article País de afiliación: Francia
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Descubrimiento de Drogas / Accidente Cerebrovascular Isquémico Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans País/Región como asunto: Africa / Asia / Europa Idioma: En Revista: Nature Año: 2022 Tipo del documento: Article País de afiliación: Francia