Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders.
Chem Commun (Camb)
; 58(85): 11913-11916, 2022 Oct 25.
Article
en En
| MEDLINE
| ID: mdl-36196950
ABSTRACT
The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Reposicionamiento de Medicamentos
/
Tratamiento Farmacológico de COVID-19
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia