Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation.

Lu, Xiaodi; Zhang, Keming; Jiang, Weiwei; Li, Hang; Huang, Yue; Du, Mingwei; Wan, Jian; Cao, Yanyun; Du, Lin; Liu, Xiaogang; Pan, Weihua

Lu, Xiaodi; Zhang, Keming; Jiang, Weiwei; Li, Hang; Huang, Yue; Du, Mingwei; Wan, Jian; Cao, Yanyun; Du, Lin; Liu, Xiaogang; Pan, Weihua.

Afiliación

Lu X; Shanghai Key Laboratory of Molecular Medicine Mycology, Naval Medical University, Shanghai, China.
Zhang K; Shanghai Key Laboratory of Molecular Medicine Mycology, Naval Medical University, Shanghai, China.
Jiang W; Shanghai Key Laboratory of Molecular Medicine Mycology, Naval Medical University, Shanghai, China.
Li H; Department of Dermatology, 72nd Group Army Hospital of People's Liberation Army (PLA), Huzhou, China.
Huang Y; Shanghai Key Laboratory of Molecular Medicine Mycology, Naval Medical University, Shanghai, China.
Du M; Shanghai Key Laboratory of Molecular Medicine Mycology, Naval Medical University, Shanghai, China.
Wan J; Shanghai Key Laboratory of Molecular Medicine Mycology, Naval Medical University, Shanghai, China.
Cao Y; Department of Dermatology, Pudong New Area People's Hospital, Shanghai, China.
Du L; Department of Dermatology, Pudong New Area People's Hospital, Shanghai, China.
Liu X; Shanghai Key Laboratory of Pathogenic Fungi Medical Testing, Pudong New Area People's Hospital, Shanghai, China.
Pan W; Shanghai Key Laboratory of Molecular Medicine Mycology, Naval Medical University, Shanghai, China.

Front Immunol ; 13: 988766, 2022.

Article en En | MEDLINE | ID: mdl-36225936

Asunto(s)

Candidiasis Mucocutánea Crónica; Candidiasis Mucocutánea Crónica/genética; Niño; Femenino; Humanos; Leucocitos Mononucleares/metabolismo; Mutación; Factor de Transcripción STAT1/metabolismo; Análisis de Secuencia de ARN; Secuenciación del Exoma

Palabras clave

chronic mucocutaneous candidiasis (CMC); heterozygous mutation; immune mechanism; signal transducer and activator of transcription 1 (STAT1); single-cell RNA sequencing (scRNAseq)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Candidiasis Mucocutánea Crónica Tipo de estudio: Prognostic_studies Límite: Child / Female / Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: China

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