Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering.

Gerlits, Oksana; Fajer, Mikolai; Cheng, Xiaolin; Blumenthal, Donald K; Radic, Zoran; Kovalevsky, Andrey

Gerlits, Oksana; Fajer, Mikolai; Cheng, Xiaolin; Blumenthal, Donald K; Radic, Zoran; Kovalevsky, Andrey.

Afiliación

Gerlits O; Department of Natural Sciences, Tennessee Wesleyan University, Athens, TN 37303, USA.
Fajer M; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
Cheng X; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Blumenthal DK; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
Radic Z; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093-0657, USA. Electronic address: zradic@ucsd.edu.
Kovalevsky A; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. Electronic address: kovalevskyay@ornl.gov.

Structure ; 30(11): 1538-1549.e3, 2022 11 03.

Article en En | MEDLINE | ID: mdl-36265484

Asunto(s)

Acetilcolinesterasa; Plaguicidas; Humanos; Acetilcolinesterasa/química; Paraoxon/química; Cristalografía por Rayos X; Inhibidores de la Colinesterasa/química; Oximas/química; Compuestos Organofosforados; Neutrones

Palabras clave

X-ray diffraction; hAChE; inelastic neutron scattering; oxime reactivator; paraoxon; vibrational dynamics

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Plaguicidas / Acetilcolinesterasa Límite: Humans Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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