Ruthenium and Nickel Molybdate-Decorated 2D Porous Graphitic Carbon Nitrides for Highly Sensitive Cardiac Troponin Biosensor.
Biosensors (Basel)
; 12(10)2022 Sep 22.
Article
en En
| MEDLINE
| ID: mdl-36290921
ABSTRACT
Two-dimensional (2D) layered materials functionalized with monometallic or bimetallic dopants are excellent materials to fabricate clinically useful biosensors. Herein, we report the synthesis of ruthenium nanoparticles (RuNPs) and nickel molybdate nanorods (NiMoO4 NRs) functionalized porous graphitic carbon nitrides (PCN) for the fabrication of sensitive and selective biosensors for cardiac troponin I (cTn-I). A wet chemical synthesis route was designed to synthesize PCN-RuNPs and PCN-NiMoO4 NRs. Morphological, elemental, spectroscopic, and electrochemical investigations confirmed the successful formation of these materials. PCN-RuNPs and PCN-NiMoO4 NRs interfaces showed significantly enhanced electrochemically active surface areas, abundant sites for immobilizing bioreceptors, porosity, and excellent aptamer capturing capacity. Both PCN-RuNPs and PCN-NiMoO4 NRs materials were used to develop cTn-I sensitive biosensors, which showed a working range of 0.1-10,000 ng/mL and LODs of 70.0 pg/mL and 50.0 pg/mL, respectively. In addition, the biosensors were highly selective and practically applicable. The functionalized 2D PCN materials are thus potential candidates to develop biosensors for detecting acute myocardial infractions.
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Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Rutenio
/
Técnicas Biosensibles
/
Grafito
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Biosensors (Basel)
Año:
2022
Tipo del documento:
Article
País de afiliación:
Arabia Saudita