Chemoproteomic profiling to identify activity changes and functional inhibitors of DNA-binding proteins.

Ruprecht, Benjamin; Wei, Lan; Zheng, Li; Bodea, Smaranda; Mo, Xuan; Maschberger, Melanie; Stoehr, Gabriele; Hahne, Hannes; Cornella-Taracido, Ivan; Chi, An

Ruprecht, Benjamin; Wei, Lan; Zheng, Li; Bodea, Smaranda; Mo, Xuan; Maschberger, Melanie; Stoehr, Gabriele; Hahne, Hannes; Cornella-Taracido, Ivan; Chi, An.

Afiliación

Ruprecht B; Chemical Biology, Merck & Co., Inc, Boston, MA 02115, USA. Electronic address: ben.ruprecht@covanttx.com.
Wei L; Chemical Biology, Merck & Co., Inc, Boston, MA 02115, USA.
Zheng L; Chemical Biology, Merck & Co., Inc, Boston, MA 02115, USA.
Bodea S; Chemical Biology, Merck & Co., Inc, Boston, MA 02115, USA.
Mo X; Chemical Biology, Merck & Co., Inc, Boston, MA 02115, USA.
Maschberger M; OmicScouts GmbH, 85354 Freising, Bavaria, Germany.
Stoehr G; OmicScouts GmbH, 85354 Freising, Bavaria, Germany.
Hahne H; OmicScouts GmbH, 85354 Freising, Bavaria, Germany.
Cornella-Taracido I; Chemical Biology, Merck & Co., Inc, Boston, MA 02115, USA.
Chi A; Chemical Biology, Merck & Co., Inc, Boston, MA 02115, USA. Electronic address: an_chi@merck.com.

Cell Chem Biol ; 29(11): 1639-1648.e4, 2022 11 17.

Article en En | MEDLINE | ID: mdl-36356585

Asunto(s)

Cisteína; Proteínas de Unión al ADN; Proteómica; Factores de Transcripción; Proteoma

Palabras clave

DNA binding; chemical proteomics; covalency; drug screening; mass spectrometry; pull-down; reactive side chain profiling

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cisteína / Proteínas de Unión al ADN Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Chem Biol Año: 2022 Tipo del documento: Article

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