Left-sided Hepatectomy Leads to Less Postoperative Liver Failure and Comparable Overall Survival to Right-sided Hepatectomy in Type II or IV Perihilar Cholangiocarcinoma.
Ann Surg Oncol
; 30(3): 1381-1390, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-36357701
ABSTRACT
INTRODUCTION:
Right-side hepatectomy (RH) is used in oncological resection for perihilar cholangiocarcinoma (PHC); however, the decision between performing left-side hepatectomy (LH) or RH is still controversial. We compared surgical and oncologic outcomes of LH and RH in PHC type II or IV where either hepatectomy was expected to have a negative margin.METHODS:
From 2001 to 2020, 99 patients underwent major liver resection for type II or IV PHC. Patients with unilateral vascular invasion, unilateral tumor growth, and atrophy of unilateral liver were excluded. Preoperative characteristics, perioperative, and long-term outcomes were compared between the remaining RH and LH patients.RESULTS:
After excluding 47 cases with side predominance, the RH group (n = 29) and LH group (n = 23) were compared. Clinical characteristics and disease severity did not differ between the groups. Portal vein embolization (RH 48.3% vs. LH 0.0%, p < 0.001) and days from diagnosis to operation (RH 31.0 ± 16.2 vs. LH 18.8 ± 13.4, p = 0.006) were significantly higher in the RH group. The RH group had statistically higher rate of postoperative hepatic failure (RH 55.2% vs. LH 21.7%, p = 0.015) and a higher mortality rate that was not significant (RH 13.8% vs. LH 0%, p = 0.120). The R0 resection rate (RH 72.4% vs. LH 78.3%, p = 0.629), median disease-free (p = 0.620), and overall (p = 0.487) survival did not differ between groups. R1 resection and lymph node metastasis were significant risk factors for disease-free survival in multivariate analysis.CONCLUSIONS:
In type II or type IV PHC where either LH or RH was feasible, LH provided a shorter period of preoperative preparation, lower postoperative hepatic failure rate, similar R0 rate, and comparable long-term outcomes. LH should be considered a reasonable option in type II or IV PHC.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de los Conductos Biliares
/
Fallo Hepático
/
Tumor de Klatskin
/
Colangiocarcinoma
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Ann Surg Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2023
Tipo del documento:
Article