Your browser doesn't support javascript.
loading
Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case report.
Wako, Sho; Ikeguchi, Ryotaro; Toda, Kunio; Kobayashi, Masaki; Miyata, Ryujin; Kuramochi, Hidekazu; Ichihara, Atsuhiro; Shimizu, Yuko; Kitagawa, Kazuo.
Afiliación
  • Wako S; Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
  • Ikeguchi R; Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: ikeguchi.ryotaro@twmu.ac.jp.
  • Toda K; Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
  • Kobayashi M; Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
  • Miyata R; Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan.
  • Kuramochi H; Department of Chemotherapy and Palliative Care, Tokyo Women's Medical University, Tokyo, Japan.
  • Ichihara A; Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
  • Shimizu Y; Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
  • Kitagawa K; Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
J Neuroimmunol ; 374: 578010, 2023 01 15.
Article en En | MEDLINE | ID: mdl-36508929
ABSTRACT
Although immune checkpoint inhibitors (ICIs) are widely used to treat unresectable malignant tumors, they can cause undesirable side effects called immune-related adverse events, including neurological toxicities. Here, we describe a case of ICI-related peripheral neuropathy (irPN) with characteristic cerebrospinal fluid (CSF) findings. In addition to pleocytosis and increased protein levels, the present case showed increased levels of CSF soluble interleukin-2 receptor (sIL-2R), IL-6, and IL-10, suggesting activated T cell-related autoimmunity. We believe that CSF cytokines and sIL-2R could be novel biomarkers of irPN.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Periférico / Neoplasias Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Periférico / Neoplasias Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article País de afiliación: Japón