Your browser doesn't support javascript.
loading
Multicenter Database of Patients with Germ-Cell Tumors: A Latin American Cooperative Oncology Group Registry (LACOG 0515).
Bastos, Diogo A; Gongora, Aline Bobato Lara; Dzik, Carlos; Jardim, Denis Leonardo; Piva, Marina; Carcano, Flavio Mavignier; Bertollo, Glaucio; Trindade, Karine; Fontes, Mariane Sousa; Soares, Andrey; Reinert, Tomas; De Cassia Costamilan, Rita; Villarroel, Rodrigo Ughini; Watarai, Gabriel; Gazola, Antonia Angeli; Preto, Daniel D Almeida; Mutti, Haila; Bonalumi Dos Santos, Marcela; Mariano, Rodrigo Coutinho; Binotto, Monique; Carvalho, Monique Maciel; Oliveira, Veronica Patrícia da Costa; Gomes, Rafaela; Rebelatto, Taiane F; Schutz, Fabio A; Smaletz, Oren; Fay, Andre P.
Afiliación
  • Bastos DA; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil; Hospital Sírio-Libanês, São Paulo, Brazil. Electronic address: diogoassed@gmail.com.
  • Gongora ABL; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil; Hospital Sírio-Libanês, São Paulo, Brazil.
  • Dzik C; Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.
  • Jardim DL; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil; Hospital Sírio-Libanês, São Paulo, Brazil.
  • Piva M; Hospital Amaral Carvalho, Jaú, Brazil.
  • Carcano FM; Barretos Cancer Hospital, Barretos, Brazil.
  • Bertollo G; AFECC - Hospital Santa Rita, Vitória, Brazil.
  • Trindade K; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil; Oncocentro, Fortaleza, Brazil.
  • Fontes MS; Grupo Oncoclínicas Botafogo, Rio de Janeiro, Brazil.
  • Soares A; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil; Centro Paulista de Oncologia/Oncoclínicas- São Paulo, São Paulo, Brazil.
  • Reinert T; Centro de Pesquisa da Serra Gaúcha (CEPESG), Caxias Do Sul, Brazil.
  • De Cassia Costamilan R; IPCEM/UCS - Fundação Universidade de Caxias do Sul - Hospital Geral, Caxias do Sul, Brazil.
  • Villarroel RU; Hospital São Vicente de Paulo, Passo Fundo, Brazil.
  • Watarai G; Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.
  • Gazola AA; Hospital São Lucas PUC-RS, Porto Alegre, Brazil; PUC-RS School of Medicine, Porto Alegre, Brazil.
  • Preto DDA; Barretos Cancer Hospital, Barretos, Brazil.
  • Mutti H; Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Bonalumi Dos Santos M; Centro Paulista de Oncologia/Oncoclínicas- São Paulo, São Paulo, Brazil.
  • Mariano RC; Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
  • Binotto M; Centro de Pesquisa da Serra Gaúcha (CEPESG), Caxias Do Sul, Brazil.
  • Carvalho MM; Oncocentro, Fortaleza, Brazil.
  • Oliveira VPDC; Hospital Amaral Carvalho, Jaú, Brazil.
  • Gomes R; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.
  • Rebelatto TF; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.
  • Schutz FA; Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
  • Smaletz O; Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Fay AP; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil; Hospital São Lucas PUC-RS, Porto Alegre, Brazil; PUC-RS School of Medicine, Porto Alegre, Brazil.
Clin Genitourin Cancer ; 21(3): e104-e113, 2023 06.
Article en En | MEDLINE | ID: mdl-36509612
INTRODUCTION: Germ-cell tumors (GCTs) are the most common malignancy in young men. There is a paucity of data on GCTs in developing countries. LACOG 0515 study aimed to evaluate clinical characteristics and treatment outcomes in patients with GCTs from Brazilian cancer centers. MATERIALS AND METHODS: This is a retrospective cohort study evaluating male patients diagnosed with GCTs from 2000 to 2018 in 13 Brazilian hospitals. We described baseline characteristics, progression-free survival (PFS), and overall survival (OS). RESULTS: A total of 1232 patients were included, with a median age of 30 years. Histology was seminoma in 47.1% and non-seminoma GCT (NSGCT) in 52.9%. The primary tumor site was testis in 96.5%. At diagnosis, clinical stage I was present in 68.1% and 34.7% and clinical stages IS/II/III in 31.9% and 65.2% of patients with seminoma and NSCGT, respectively. Following orchiectomy, 55.2% of patients with clinical stage I were managed with surveillance. The 5-year disease-free survival rates among patients with stage I were 98.0% in seminoma and 92.3% in NSGCT, with 5-year OS of 99.6% and 97.6%, respectively. Among patients with advanced disease (IS, II, and III), the 5-year PFS were 88.7% in seminoma and 68.7% in NSGCT, with 5y-OS of 97.6% and 82.8%, respectively. CONCLUSION: This is the largest Brazilian cohort of GCTs. Our results show a high rate of adjuvant chemotherapy in patients with clinical stage I. Although our data demonstrate slightly inferior PFS compared with the International Germ Cell Cancer Collaborative Group and other contemporary series, the OS rates were similar.
Asunto(s)
Palabras clave

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Seminoma / Neoplasias de Células Germinales y Embrionarias Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Clin Genitourin Cancer Asunto de la revista: NEOPLASIAS / UROLOGIA Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Seminoma / Neoplasias de Células Germinales y Embrionarias Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Clin Genitourin Cancer Asunto de la revista: NEOPLASIAS / UROLOGIA Año: 2023 Tipo del documento: Article