Expanding the Therapeutic Window of EGFR-Targeted PE24 Immunotoxin for EGFR-Overexpressing Cancers by Tailoring the EGFR Binding Affinity.

Jun, Sei-Yong; Kim, Dae-Seong; Kim, Yong-Sung

Jun, Sei-Yong; Kim, Dae-Seong; Kim, Yong-Sung.

Afiliación

Jun SY; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
Kim DS; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
Kim YS; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.

Int J Mol Sci ; 23(24)2022 Dec 13.

Article en En | MEDLINE | ID: mdl-36555466

Asunto(s)

Antineoplásicos; Inmunotoxinas; Neoplasias; Humanos; Ratones; Animales; Inmunotoxinas/farmacología; Inmunotoxinas/uso terapéutico; Receptores ErbB/metabolismo; Línea Celular Tumoral; Anticuerpos; Antígenos de Neoplasias; Neoplasias/tratamiento farmacológico

Palabras clave

PE24 toxin; affinity variants; anti-EGFR monobody; immunotoxin; on-target/off-tumor toxicity; therapeutic index; therapeutic window

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Inmunotoxinas / Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article

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