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Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
Kanada, Ryutaro; Kagoshima, Yoshiko; Suzuki, Takashi; Nakamura, Akifumi; Funami, Hideaki; Watanabe, Jun; Asano, Masayoshi; Takahashi, Mizuki; Ubukata, Osamu; Suzuki, Kanae; Aikawa, Tomoya; Sato, Kazumi; Goto, Megumi; Setsu, Genzui; Ito, Kentaro; Kihara, Kawori; Kuroha, Mutsumi; Kohno, Takashi; Ogiwara, Hideaki; Isoyama, Takeshi; Tominaga, Yuichi; Higuchi, Saito; Naito, Hiroyuki.
Afiliación
  • Kanada R; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Kagoshima Y; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Suzuki T; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Nakamura A; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Funami H; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Watanabe J; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Asano M; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Takahashi M; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo134-8630, Japan.
  • Ubukata O; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo134-8630, Japan.
  • Suzuki K; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Aikawa T; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Sato K; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo134-8630, Japan.
  • Goto M; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Setsu G; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Ito K; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Kihara K; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo134-8630, Japan.
  • Kuroha M; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo134-8630, Japan.
  • Kohno T; Division of Genome Biology, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo104-0045, Japan.
  • Ogiwara H; Division of Cancer Therapeutics, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo104-0045, Japan.
  • Isoyama T; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Tominaga Y; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Higuchi S; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
  • Naito H; Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo140-8710, Japan.
J Med Chem ; 66(1): 695-715, 2023 01 12.
Article en En | MEDLINE | ID: mdl-36572866
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Histonas / Histona Acetiltransferasas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Histonas / Histona Acetiltransferasas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón