Solid-phase capture and profiling of open chromatin by spatial ATAC.
Nat Biotechnol
; 41(8): 1085-1088, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-36604544
ABSTRACT
Current methods for epigenomic profiling are limited in their ability to obtain genome-wide information with spatial resolution. We introduce spatial ATAC, a method that integrates transposase-accessible chromatin profiling in tissue sections with barcoded solid-phase capture to perform spatially resolved epigenomics. We show that spatial ATAC enables the discovery of the regulatory programs underlying spatial gene expression during mouse organogenesis, lineage differentiation and in human pathology.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cromatina
/
Transposasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Suecia