Vestibular Implantation Can Work Even After More Than 20 Years of Bilateral Vestibular Hypofunction.
Otol Neurotol
; 44(2): 168-171, 2023 02 01.
Article
en En
| MEDLINE
| ID: mdl-36624598
ABSTRACT
OBJECTIVE:
To determine whether prosthetic stimulation delivered via a vestibular implant can elicit artificial sensation of head movement despite long (23-yr) duration adult-onset ototoxic bilateral vestibular hypofunction (BVH). STUDYDESIGN:
Case report.SETTING:
Tertiary care center as part of a first-in-human clinical trial. PATIENTS One.INTERVENTIONS:
Unilateral vestibular implantation with an investigational multichannel vestibular implant in a 55-year-old man with a well-documented 23-year history of aminoglycoside-induced BVH. MAIN OUTCOMEMEASURES:
Electrically evoked vestibulo-ocular reflexes (eeVOR).RESULTS:
Vestibular implant stimulation can drive stimulus-aligned eeVOR and elicit a vestibular percept 23 years after the onset of bilateral vestibulopathy. Prosthetic stimulation targeting individual semicircular canals elicited eye movements that approximately aligned with each targeted canal's axis. The magnitude of the eeVOR response increased with increasing stimulus current amplitude. Response alignment and magnitude were similar to those observed for implant recipients who underwent vestibular implantation less than 10 years after BVH onset. Responses were approximately stable for 18 months of continuous device use (24 h/d except during sleep).CONCLUSIONS:
Vestibular implantation and prosthetic electrical stimulation of semicircular canal afferent nerves can drive canal-specific eye movement responses more than 20 years after the onset of ototoxic vestibular hypofunction.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vestíbulo del Laberinto
/
Vestibulopatía Bilateral
/
Ototoxicidad
Límite:
Adult
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Otol Neurotol
Asunto de la revista:
NEUROLOGIA
/
OTORRINOLARINGOLOGIA
Año:
2023
Tipo del documento:
Article