3' untranslated region variants in DEFA5 gene associated with susceptibility to IgA nephropathy in the Chinese Han population.
Biomark Med
; 16(16): 1151-1159, 2022 11.
Article
en En
| MEDLINE
| ID: mdl-36632813
ABSTRACT
Aim:
To evaluate the association between single-nucleotide polymorphisms in the 3' untranslated region of the DEFA5 gene and IgA nephropathy (IgAN) risk, the authors performed an association study in the Chinese Han population. Materials &methods:
The authors recruited 426 IgAN patients and 498 controls. The MassARRAY platform (Agena Bioscience, Inc., CA, USA) was used to genotype single-nucleotide polymorphisms in DEFA5. Odds ratios and 95% CIs were calculated through logistic regression analysis.Results:
The authors observed that rs12716641 significantly reduced IgAN risk in the allele (odds ratio 0.77; p = 0.026) and genotype (odds ratio 0.75; p = 0.039) models. Stratification analysis revealed that several genotypes of rs12716641 played a protective role against IgAN.Conclusion:
The authors' results revealed that single-nucleotide polymorphisms in the 3' untranslated region of DEFA5 were associated with IgAN risk.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Glomerulonefritis por IGA
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Biomark Med
Asunto de la revista:
BIOQUIMICA
/
MEDICINA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China