Cohort-guided insights into gene-environment interactions in autism spectrum disorders.
Nat Rev Neurol
; 19(2): 118-125, 2023 02.
Article
en En
| MEDLINE
| ID: mdl-36646930
ABSTRACT
Prospective birth cohorts offer unprecedented opportunities to investigate the pathogenesis of complex disorders such as autism, in which gene-environment interactions must be appreciated in a temporal context. This Perspective article considers the history of autism research, including missteps that reflected an incomplete understanding of the epidemiology of autistic spectrum disorders, the effects of advocacy and philanthropy on the trajectory of scientific inquiry, and the current and future roles of prospective birth cohort research in illuminating the pathology of these and other complex disorders wherein exposures during gestation might not manifest until later in life.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trastorno Autístico
/
Trastorno del Espectro Autista
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Nat Rev Neurol
Asunto de la revista:
NEUROLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos